Nervous System Overview-An Introduction to Its Structure and Functions

Nervous System Overview-An Introduction to Its Structure and Functions

Nervous System Overview-An Introduction to Its Structure and Functions

Nervous System Overview: Understanding CNS and PNS Functions

The nervous system is a complicated network that regulates the body’s operations. In this Nervous System Overview, we’ll look at the two main components: the Central Nervous System (CNS) and the Peripheral Nervous System (PNS), and how they operate together to regulate critical bodily activities.

 Functions of Brain

The brain is responsible for sensory input interpretation, muscle movement control, body temperature regulation, and higher cognitive activities such as memory, thinking, and decision-making.

 Functions of Spinal Cord

The spinal cord serves as an important communication channel between the brain and the Peripheral Nervous System (PNS). It sends messages to control reflexes and movement. Damage to the spinal cord can significantly impair body control and nervous function.


Peripheral Nervous System (PNS) Functions

The Peripheral Nervous System refers to all the nerves outside the brain and spinal cord. Its primary job is to connect the CNS to the body’s limbs and organs, ensuring that brain signals reach muscles, skin, and internal organs. The PNS is organized into two main subsystems: the somatic nervous system and the autonomic nervous system.

Somatic Nervous System

The somatic nervous system regulates voluntary motions like walking and grasping objects by transmitting signals from the brain to the muscles. It also controls reflex actions, such as retreating from a hot surface.

Autonomic Nervous System

The autonomic nervous system regulates involuntary actions like heart rate, digestion, and breathing. It has two major branches:

 

Credit- https://copbela.org/

 

Summary of Nervous System Overview

In summary, the human nervous system has two major branches: the Central Nervous System (CNS), which includes the brain and spinal cord, and the Peripheral Nervous System (PNS), which connects the CNS to the rest of the body. The somatic nervous system regulates deliberate movements, whereas the autonomic nervous system governs involuntary actions. The autonomic system is further divided into two systems: sympathetic and parasympathetic, which govern stress and relaxation responses, respectively.

"Classification of the nervous system flowchart showing divisions into central nervous system (CNS) and peripheral nervous system (PNS), with further breakdown into somatic and autonomic nervous systems, including sympathetic and parasympathetic nervous system branches."

“This flowchart illustrates the detailed classification of the human nervous system, outlining its major components: the central nervous system (CNS), peripheral nervous system (PNS), somatic system, autonomic system, and further subdivisions including sympathetic and parasympathetic branches.”

🧬 Common Receptors, Substrates and Drug Examples 💊

Receptor

Endogenous Substrate

Agonist Action

Drug Agonists

Antagonist Action

Drug Antagonists

Muscarinic

Acetylcholine

↑ SLUDD

Pilocarpine, Bethanechol

↓ SLUDD

Atropine

Oxybutynin

Nicotinic

Acetylcholine

↑ HR, BP

Nicotine

Neuromuscular blockade

Neuromuscular blockers

(e.g., Rocuronium)

Alpha-1

Epinephrine, Norepinephrine

Smooth muscle vasoconstriction, ↑ BP

Phenylephrine, Dopamine (dose-dependent)

Smooth muscle vasodilation, ↓ BP

Alpha-1 blockers

(e.g., Doxazosin, Carvedilol, Phentolamine)

Alpha-2

Epinephrine, Norepinephrine

↓ Release of epinephrine, norepinephrine, ↓ BP, HR

Clonidine, Brimonidine

↑ BP, HR

Ergot alkaloids, Yohimbine

Beta-1

Epinephrine, Norepinephrine

↑ Myocardial contractility, CO, HR

Dobutamine, Isoproterenol

↓ CO, HR

Beta-1 blockers

 (e.g., Metoprolol, Propranolol, Carvedilol)

Beta-2

Epinephrine

Bronchodilation

Albuterol, Terbutaline, Isoproterenol

Bronchoconstriction

Non-selective beta-blockers (e.g., Propranolol, Carvedilol)

Dopamine

Dopamine

Renal, cardiac, CNS effects

Levodopa, Pramipexole

Many effects on renal, cardiac, CNS

First-gen antipsychotics

 (e.g., Haloperidol), Metoclopramide

Serotonin

Serotonin

Platelet, GI, psychiatric effects

Triptans (e.g., Sumatriptan)

Many effects on platelet, GI, psychiatric

Ondansetron, Second-gen antipsychotics

 (e.g., Quetiapine)

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