Crohn’s disease is a chronic, relapsing inflammatory bowel disease characterized by transmural inflammation that can affect any part of the gastrointestinal tract, most commonly the terminal ileum and proximal colon. This comprehensive 2026 guide explains everything from early symptoms such as chronic diarrhea, abdominal pain, weight loss, and perianal disease to advanced diagnostic methods including colonoscopy with biopsy, fecal calprotectin, and imaging studies.
The article also explores hallmark endoscopic and pathological features such as skip lesions, cobblestone appearance, strictures, and string sign. A detailed comparison with ulcerative colitis helps in clinical differentiation.
Finally, the guide covers modern treatment strategies including corticosteroids, aminosalicylates, immunosuppressants (thiopurines, methotrexate), biologics (anti-TNF agents, ustekinumab, risankizumab), and integrin receptor antagonists (vedolizumab, natalizumab), providing a complete evidence-based overview for medical students and clinicians. …
Read More…….Crohn’s Disease: Symptoms, Causes, Diagnosis & Treatment (2026 Guide)