Gastro-oesophageal reflux disease (GORD/ GERD) Gastric Acid Secretion, Proton Pump Mechanism, and GERD Explained The human stomach plays a central role in digestion by producing hydrochloric acid (HCl), which helps break down food, activate digestive enzymes, and eliminate harmful microorganisms. This acid secretion is tightly regulated by specialized cells and hormonal signals to maintain digestive efficiency and protect the gastrointestinal tract. How Stomach Acid is Produced Parietal cells located in the epithelial lining of the stomach are responsible for secreting hydrochloric acid (HCl). This process occurs through the hydrogen-potassium adenosine triphosphatase (H⁺/K⁺-ATPase) pump, commonly known as the proton pump. This
Gastro-oesophageal reflux disease (GORD/ GERD)
By
hemanthbesabathini@gmail.com
Gastroenterology
acid reflux mechanism, cimetidine interactions, CYP450 inhibitors, famotidine precautions, gastric acid secretion, GERD causes, H2RA drug interactions, histamine acetylcholine gastrin, lower esophageal sphincter function, parietal cells stomach, proton pump H+/K+ ATPase, stomach acid regulation
